Data Driven College Basketball Predictions for February 21, 2016:
| TEAM | WIN % | SCORE | VEGAS LINE |
| 821 La Salle | 28% | 61 | 137½u |
| 822 George Washington | 72% | 80 | -16 |
| 823 Seton Hall | 63% | 76 | -11½ |
| 824 St. Johns | 37% | 64 | 143½u |
| 825 Illinois | 38% | 65 | 133½u |
| 826 Wisconsin | 62% | 76 | -11½ |
| 827 Northeastern | 42% | 71 | 146u |
| 828 Hofstra | 58% | 78 | -7 |
| 829 East Carolina | 27% | 62 | 145u |
| 830 SMU | 73% | 82 | -19 |
| 831 Tulsa | 56% | 74 | -8 |
| 832 Central Florida | 44% | 68 | 138½u |
| 833 Detroit | 31% | 67 | 150½u |
| 834 Valparaiso | 69% | 84 | -14 |
| 835 Loyola-Chicago | 48% | 67 | 134u |
| 836 Missouri State | 52% | 68 | -2 |
| 837 George Mason | 43% | 70 | 144½u |
| 838 Massachusetts | 57% | 76 | -6 |
| 839 Michigan | 45% | 69 | 140u |
| 840 Maryland | 55% | 73 | -9 |
| 841 San Diego State | 61% | 72 | -8½ |
| 842 San Jose State | 39% | 62 | 124u |
| 843 Wichita State | 60% | 73 | -11½ |
| 844 Indiana State | 40% | 64 | 134½u |
| 845 Oakland | 68% | 85 | -14½ |
| 846 Illinois-Chicago | 32% | 69 | 163½u |
| 847 UAB | 48% | 71 | 140½u |
| 848 Middle Tennessee St. | 52% | 72 | -2½ |
| 849 Utah | 47% | 75 | 149u |
| 850 Southern Cal | 53% | 77 | -3 |
| 851 Boston College | 37% | 66 | 138½u |
| 852 Wake Forest | 63% | 77 | -8 |
| 853 Temple | 44% | 69 | 141u |
| 854 Houston | 56% | 74 | -4 |
| 855 California | 60% | 77 | -10½ |
| 856 Washington State | 40% | 68 | 142½u |
| 857 Monmouth (NJ) | 59% | 76 | -7½ |
| 858 St. Peters | 41% | 68 | 139u |
| 859 Manhattan | 47% | 69 | 133½u |
| 860 Quinnipiac | 53% | 72 | -2 |
| 861 Denver | 45% | 70 | 136½u |
| 862 South Dakota | 55% | 74 | -4½ |
| 863 Boston University | 44% | 72 | 155u |
| 864 Bucknell | 56% | 78 | -7 |
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