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Data Driven MLB Predictions for April 22, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Mets | Harvey | 73% | 4 | -180 | 7.5 |
| Braves | Norris | 27% | 3 | +160 | |
| Cubs | Lester | 61% | 5 | -200 | 8 |
| Reds | Moscot | 39% | 4 | +180 | |
| Phillies | Nola | 48% | 3 | +110 | 8.5 |
| Brewers | Davies | 52% | 4 | -120 | |
| Dodgers | Kazmir | 58% | 5 | -125 | 11 |
| Rockies | Gray | 42% | 4 | +115 | |
| Pirates | Niese | 44% | 3 | +120 | 8.5 |
| Diamondbacks | Corbin | 56% | 4 | -130 | |
| Marlins | Cosart | 42% | 4 | +150 | 7.5 |
| Giants | Samardzija | 58% | 5 | -160 | |
| Cardinals | Wainwright | 54% | 4 | -130 | 7.5 |
| Padres | Cashner | 46% | 3 | +120 | |
| Rays | Moore | 37% | 4 | -108 | 8 |
| Yankees | Sabathia | 63% | 5 | -102 | |
| A’s | Gray | 28% | 3 | +125 | 8 |
| Blue Jays | Sanchez | 72% | 4 | -135 | |
| Indians | Tomlin | 37% | 3 | +122 | 8.5 |
| Tigers | Verlander | 63% | 4 | -132 | |
| Rangers | Perez | 47% | 4 | +140 | 8 |
| White Sox | Quintana | 53% | 5 | -150 | |
| Red Sox | Wright | 48% | 3 | +135 | 9 |
| Astros | McHugh | 52% | 4 | -145 | |
| Orioles | Gallardo | 43% | 3 | +108 | 9 |
| Royals | Young | 57% | 4 | -118 | |
| Mariners | Hernandez | 48% | 4 | -118 | 7 |
| Angels | Tropeano | 52% | 5 | +108 | |
| Twins | Gibson | 36% | 4 | +165 | 7.5 |
| Nationals | Gonzalez | 64% | 5 | -180 |
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