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Data Driven MLB Predictions for August 22, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Rockies | Gray | 52% | 5 | -135 | 9 |
| Brewers | Anderson | 48% | 4 | +125 | |
| Mets | Niese | 45% | 4 | ||
| Cardinals | Garcia | 55% | 5 | ||
| Braves | Whalen | 49% | 4 | +143 | 9.5 |
| Diamondbacks | Bradley | 51% | 5 | -153 | |
| Cubs | Arrieta | 54% | 5 | ||
| Padres | Friedrich | 46% | 4 | ||
| Giants | Bumgarner | 51% | 5 | ||
| Dodgers | Maeda | 49% | 4 | ||
| Angels | Skaggs | 47% | 4 | +144 | |
| Blue Jays | Dickey | 53% | 5 | -154 | |
| Red Sox | Buchholz | 50% | 5 | +100 | 8 |
| Rays | Archer | 50% | 4 | -110 | |
| Tigers | Sanchez | 48% | 5 | -115 | 9 |
| Twins | Gibson | 52% | 6 | +105 | |
| Indians | Salazar | 54% | 5 | -153 | 7.5 |
| A’s | Manaea | 46% | 4 | +143 | |
| Yankees | Sabathia | 47% | 4 | ||
| Mariners | Iwakuma | 53% | 5 | ||
| Astros | Musgrove | 50% | 4 | ||
| Pirates | Nova | 50% | 5 | ||
| Nationals | Lopez | 49% | 4 | +123 | 9 |
| Orioles | Gausman | 51% | 5 | -133 | |
| Rangers | Holland | 49% | 4 | -113 | 9 |
| Reds | Straily | 51% | 5 | +103 | |
| Royals | Ventura | 49% | 4 | -107 | 8 |
| Marlins | Cashner | 51% | 5 | -103 | |
| Phillies | Thompson | 51% | 5 | +158 | 9 |
| White Sox | Ranaudo | 49% | 4 | -168 |
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