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Data Driven MLB Predictions for July 22, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Phillies | Eflin | 43% | 3 | +185 | 8 |
| Pirates | Cole | 57% | 5 | -200 | |
| Padres | Perdomo | 38% | 4 | +207 | 9 |
| Nationals | Roark | 62% | 6 | -225 | |
| Diamondbacks | Bradley | 50% | 4 | +112 | 9.5 |
| Reds | Straily | 50% | 5 | -122 | |
| Mets | Verrett | 47% | 3 | +125 | 8.5 |
| Marlins | Conley | 53% | 4 | -135 | |
| Cubs | Hammel | 54% | 4 | -168 | 8.5 |
| Brewers | Nelson | 46% | 3 | +158 | |
| Dodgers | McCarthy | 47% | 4 | -105 | 8 |
| Cardinals | Wacha | 53% | 5 | -105 | |
| Braves | Teheran | 48% | 4 | +125 | 11 |
| Rockies | Gray | 52% | 5 | -135 | |
| Indians | Bauer | 49% | 4 | -103 | 9 |
| Orioles | Bundy | 51% | 5 | -107 | |
| Mariners | Paxton | 45% | 4 | +145 | 9 |
| Blue Jays | Estrada | 55% | 5 | -155 | |
| Twins | Gibson | 50% | 5 | +174 | 10.5 |
| Red Sox | Rodriguez | 50% | 6 | -184 | |
| Tigers | Fulmer | 57% | 5 | -142 | 9 |
| White Sox | Turner | 43% | 4 | +132 | |
| Angels | Shoemaker | 47% | 4 | +136 | 8 |
| Astros | McCullers | 53% | 5 | -146 | |
| Rangers | Darvish | 51% | 5 | +100 | 8 |
| Royals | Duffy | 49% | 4 | -110 | |
| Rays | Odorizzi | 50% | 4 | +110 | 8 |
| A’s | Manaea | 50% | 5 | -120 | |
| Giants | Bumgarner | 53% | 4 | -129 | 7.5 |
| Yankees | Tanaka | 47% | 3 | +119 |
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