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Data Driven MLB Predictions for June 22, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE |
| Braves | Wisler | 46% | 3 | +149 |
| Marlins | Conley | 54% | 4 | -159 |
| Cardinals | Wacha | 32% | 2 | +245 |
| Cubs | Arrieta | 68% | 5 | -270 |
| Giants | Samardzija | 58% | 5 | -108 |
| Pirates | Liriano | 42% | 4 | -102 |
| Nationals | Ross | 56% | 4 | +111 |
| Dodgers | Urias | 44% | 3 | -121 |
| Angels | Shoemaker | 48% | 4 | +142 |
| Astros | McCullers | 52% | 5 | -152 |
| White Sox | Quintana | 56% | 4 | -101 |
| Red Sox | Rodriguez | 44% | 3 | -109 |
| Rays | Archer | 43% | 4 | +108 |
| Indians | Bauer | 57% | 5 | -118 |
| Mariners | Iwakuma | 40% | 3 | +118 |
| Tigers | Fulmer | 60% | 4 | -128 |
| Rockies | Gray | 37% | 3 | +151 |
| Yankees | Sabathia | 63% | 5 | -161 |
| Royals | Duffy | 39% | 2 | +181 |
| Mets | Syndergaard | 61% | 3 | -191 |
| Brewers | Guerra | 52% | 4 | +101 |
| A’s | Mengden | 48% | 3 | -111 |
| Diamondbacks | Ray | 43% | 4 | +158 |
| Blue Jays | Happ | 57% | 5 | -168 |
| Padres | Johnson | 56% | 6 | |
| Orioles | Jimenez | 44% | 5 | |
| Reds | Straily | 43% | 3 | +185 |
| Rangers | Hamels | 57% | 4 | -200 |
| Phillies | Morgan | 48% | 5 | +141 |
| Twins | Gibson | 52% | 6 | -151 |
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