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Data Driven MLB Predictions for May 21, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Diamondbacks | Ray | 47% | 4 | +132 | 8 |
| Cardinals | Leake | 53% | 5 | -142 | |
| Braves | Perez | 48% | 3 | +121 | 8.5 |
| Phillies | Morgan | 52% | 4 | -131 | |
| Rockies | Chatwood | 53% | 5 | +119 | 8 |
| Pirates | Niese | 47% | 4 | -129 | |
| Brewers | Davies | 44% | 3 | +207 | 7 |
| Mets | deGrom | 56% | 5 | -225 | |
| Nationals | Ross | 51% | 4 | +137 | 7 |
| Marlins | Fernandez | 49% | 3 | -147 | |
| Cubs | Lester | 59% | 6 | -148 | 7 |
| Giants | Cain | 41% | 3 | +138 | |
| Dodgers | Wood | 50% | 4 | -134 | 7.5 |
| Padres | Vargas | 50% | 5 | +124 | |
| Royals | Duffy | 47% | 3 | -110 | 9 |
| White Sox | Gonzalez | 53% | 4 | +100 | |
| Blue Jays | Happ | 53% | 4 | -146 | 9 |
| Twins | Dean | 47% | 3 | +136 | |
| Yankees | Tanaka | 51% | 5 | -131 | 7.5 |
| A’s | Manaea | 49% | 4 | +121 | |
| Indians | Bauer | 45% | 4 | +117 | 9 |
| Red Sox | Kelly | 55% | 5 | -127 | |
| Rays | Smyly | 50% | 5 | -135 | 8.5 |
| Tigers | Fulmer | 50% | 4 | +125 | |
| Rangers | Ramos | 52% | 5 | +138 | 9 |
| Astros | Fiers | 48% | 4 | -150 | |
| Orioles | Gausman | 60% | 6 | -127 | 8 |
| Angels | Shoemaker | 40% | 4 | +117 | |
| Mariners | Hernandez | 56% | 5 | -163 | 8 |
| Reds | Lamb | 44% | 4 | +153 |
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