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Data Driven MLB Predictions for May 22, 2016:
| TEAM | PITCHER | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Nationals | Scherzer | 49% | 4 | -136 | 7 |
| Marlins | Conley | 51% | 5 | +126 | |
| Brewers | Anderson | 44% | 3 | +210 | 7 |
| Mets | Syndergaard | 56% | 5 | -240 | |
| Rockies | Bettis | 50% | 5 | +120 | 8 |
| Pirates | Nicasio | 50% | 4 | -130 | |
| Braves | Kelly | 45% | 4 | ||
| Phillies | Eickhoff | 55% | 5 | ||
| Diamondbacks | Greinke | 43% | 4 | +117 | 7 |
| Cardinals | Garcia | 57% | 5 | -127 | |
| Dodgers | Maeda | 53% | 4 | -160 | 7.5 |
| Padres | Rea | 47% | 3 | +150 | |
| Cubs | Hendricks | 51% | 5 | +110 | 7 |
| Giants | Bumgarner | 49% | 4 | -120 | |
| Rays | Archer | 46% | 3 | +105 | 8 |
| Tigers | Zimmermann | 54% | 4 | -115 | |
| Indians | Salazar | 48% | 3 | +100 | 8.5 |
| Red Sox | Porcello | 52% | 4 | -110 | |
| Rangers | Hamels | 54% | 5 | +125 | 8 |
| Astros | Keuchel | 46% | 4 | -135 | |
| Royals | Ventura | 47% | 4 | -105 | 8.5 |
| White Sox | Rodon | 53% | 5 | -105 | |
| Blue Jays | Stroman | 53% | 5 | -150 | 8.5 |
| Twins | Hughes | 47% | 4 | +140 | |
| Orioles | Jimenez | 52% | 6 | -116 | 9 |
| Angels | Weaver | 48% | 5 | +106 | |
| Yankees | Pineda | 44% | 4 | -115 | 8 |
| A’s | Hahn | 56% | 5 | +105 | |
| Mariners | Miley | 60% | 7 | -150 | 9 |
| Reds | Simon | 40% | 4 | +140 |
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