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MLB Predictions for September 21, 2016:
| TEAM | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Cardinals | 50% | 5 | -135 | 12.5 |
| Rockies | 50% | 4 | +125 | |
| Braves | 45% | 4 | +185 | 8.5 |
| Mets | 55% | 5 | -200 | |
| Nationals | 53% | 5 | -185 | 7.5 |
| Marlins | 47% | 4 | +175 | |
| Reds | 45% | 4 | +220 | |
| Cubs | 55% | 5 | -240 | |
| Pirates | 51% | 5 | -110 | 9 |
| Brewers | 49% | 4 | +100 | |
| Diamondbacks | 52% | 5 | -133 | 7.5 |
| Padres | 48% | 4 | +123 | |
| Giants | 48% | 4 | +140 | 7.5 |
| Dodgers | 52% | 5 | -150 | |
| Astros | 52% | 5 | -136 | 8.5 |
| A’s | 48% | 4 | +126 | |
| Blue Jays | 50% | 5 | -110 | 8 |
| Mariners | 50% | 4 | +100 | |
| Red Sox | 52% | 6 | -115 | 10 |
| Orioles | 48% | 5 | +105 | |
| Yankees | 50% | 4 | -125 | 7 |
| Rays | 50% | 5 | +115 | |
| Royals | 47% | 4 | +176 | 7.5 |
| Indians | 53% | 5 | -186 | |
| Angels | 46% | 4 | +170 | 10 |
| Rangers | 54% | 5 | -180 | |
| Tigers | 54% | 6 | ||
| Twins | 46% | 5 | ||
| White Sox | 52% | 5 | -155 | 7.5 |
| Phillies | 48% | 4 | +145 |
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