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MLB Predictions for September 22, 2016:
| TEAM | WIN % | SCORE | VEGAS LINE | RUN TOTAL |
| Braves | 49% | 4 | +145 | 8.5 |
| Marlins | 51% | 5 | -155 | |
| Phillies | 43% | 3 | +190 | 8 |
| Mets | 57% | 5 | -205 | |
| Pirates | 49% | 4 | -105 | 9.5 |
| Brewers | 51% | 5 | -105 | |
| Giants | 51% | 5 | -148 | 8 |
| Padres | 49% | 4 | +!38 | |
| Rockies | 50% | 4 | +167 | 8 |
| Dodgers | 50% | 5 | -177 | |
| Red Sox | 51% | 5 | -140 | 8.5 |
| Orioles | 49% | 4 | +130 | |
| Yankees | 48% | 4 | +111 | 8 |
| Rays | 52% | 5 | -121 | |
| Royals | 48% | 4 | +144 | 9 |
| Indians | 52% | 5 | -154 | |
| Tigers | 50% | 3 | -134 | 8.5 |
| Twins | 50% | 4 | +124 | |
| Angels | 48% | 4 | +159 | 8.5 |
| Astros | 52% | 5 | -169 |
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